methadone liquid-oral
GENERIC NAME: METHADONE LIQUID - ORAL (METH-uh-doan)
|Warning |Medication Uses |How To Use |Side Effects |Precautions |Drug Interactions |Overdose |Notes |Missed Dose |Storage|
|WARNING:| Methadone is to be taken by mouth only. It must not be injected. Methadone is a synthetic narcotic. Patients who are physically dependent on narcotics may have withdrawal symptoms if given the usual dose of a narcotic antagonist (e.g., naloxone, naltrexone). If a narcotic antagonist must be given, the dose must be smaller than the usual dose and it must be given with extreme care. Withdrawal symptoms may also be caused by using certain narcotics (partial agonist/antagonists such as pentazocine, butorphanol, nalbuphine) after using methadone. Tell your doctor immediately if you develop symptoms such as anxiety, agitation, and |diarrhea|.
|USES:| This is used for narcotic addiction or for severe pain. Methadone is a potent narcotic substance. It can cause serious side effects and toxic reactions if used by someone other than the person for whom it is prescribed. Do not share this medication with others.
|HOW TO USE:| Take this medication only by mouth. To prevent upset stomach, take with food or milk. Take this as prescribed. Do not increase your dose, take it more frequently or use it for a longer period of time without your doctor's approval. Also, if used for a long period of time at high doses, do not suddenly stop taking this without first consulting your doctor. When used for extended periods, this medication may not work as well and may require different dosing. Consult your doctor if the medication isn't working properly.
|SIDE EFFECTS:| May cause |constipation|, lightheadedness, dizziness, drowsiness, stomach upset, nausea, and flushing the first few days as your body adjusts to the medication. If these symptoms persist or become bothersome, inform your doctor. To minimize constipation, increase your intake of |fiber|, drink plenty of water, and exercise. Stool softeners may be helpful. Ask your doctor or pharmacist about stool softeners and laxatives. Notify your doctor if you develop: irregular heartbeat, anxiety, tremors, seizures. In the unlikely event you have a serious allergic reaction to this drug, seek medical attention immediately. Symptoms of a serious allergic reaction include: |rash|, itching, swelling, severe dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.
- |methadone liquid-oral Index|
- |Glossary|
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the |FDA MedWatch| website or call 1-800-FDA-1088.
methadone liquid-oral (cont.)
|PRECAUTIONS:| Tell your doctor your medical history, especially of: stomach problems (e.g., colitis), substance abuse problems, uncorrected low mineral levels in the blood (e.g., potassium and magnesium), certain heart diseases (cardiac hypertrophy, cardiac conduction conditions--e.g., prolonged QT interval), any allergies. Use caution engaging in activities requiring alertness such as driving or using machinery. Alcoholic beverages may add to the effects of this medication causing dizziness or drowsiness. Ask your doctor or pharmacist about alcohol use. Caution is advised when using this drug in the elderly because they may be more sensitive to the effects of the drug. This medication should be used only when clearly needed during |pregnancy|. Discuss the risks and benefits with your doctor. This drug is excreted into |breast| milk and may affect the infant. Consult your doctor before breast-feeding.
|DRUG INTERACTIONS:| Tell your doctor of all prescription and nonprescription drugs you use, especially of: MAO inhibitors (e.g., furazolidone, linezolid, phenelzine, selegiline, tranylcypromine), psychiatric drugs (e.g., desipramine), tranquilizers, |sleep| medications (e.g., zolpidem), zidovudine, didanosine, stavudine, nevirapine, efavirenz, ritonavir, ritonavir/lopinavir, other narcotic pain relievers, drugs which affect certain liver enzymes (CYP 3A4 substrates, inhibitors, and inducers such as St John's wort, cimetidine, azole antifungals--itraconazole, macrolide antibiotics--erythromycin, rifamycins--rifampin, certain anti-seizure medications--phenobarbital, phenytoin, carbamazepine), certain antihistamines (e.g., diphenhydramine) or other drugs which can also cause drowsiness. Other drugs besides methadone which may affect the heart rhythm (QTc prolongation in the EKG) include dofetilide, pimozide, procainamide, quinidine, sotalol, sparfloxacin, "water pills" (diuretics such as furosemide), and laxatives among others. QTc prolongation can infrequently result in serious, rarely fatal, irregular heartbeats. Other symptoms may include unusual dizziness or |fainting|. Seek immediate medical attention should these occur. Consult your doctor or pharmacist for details. Ask for instructions about whether you need to stop any other QTc-prolonging drugs you may be using in order to minimize the risk of this effect. Do not start or stop any medicine without doctor or pharmacist approval.
|OVERDOSE:| If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly. Symptoms of overdose may include cold and clammy skin, low body temperature, slowed breathing, slowed heartbeat, drowsiness, dizziness, lightheadedness, deep sleep, and loss of consciousness.
|NOTES:| Do not share this medication with others. It is against the law. Laboratory and/or medical tests (e.g., EKG-QTc interval) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.
|MISSED DOSE:| If you miss a dose, take as soon as remembered; do not take if it is almost time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.
|STORAGE:| Store at room temperature between 59 and 86 degrees F (between 15 and 30 degrees C) away from moisture and sunlight. Do not store in the bathroom.
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